Dentist are using various materials to treat a tooth. All these treatments have a cytotoxic response of the tooth. New treatment models are needed to research these reactions more extensively. Scientist from the Department of Restorative Dentistry, School of Dentistry, Oregon Health & Science University, Portland, OR, USA have developed a new research model.
The tooth-on-a-chip device - showing the molar material in the middle. Credits: OHSU Kristyna Wentz-Graff
The tooth (pulp) has a unique composition. Various biomaterials are used by dentists to treat a tooth. Although the cytotoxic response of the tooth to biomaterials has been extensively studied, there is a shortage of "in vitro" model systems that simulate dental treatment with biomaterials. However, an even better understanding of the influence of biomaterials on living tooth (pulp) is desirable. To address this shortage, a tooth-on-chip model system has been developed. The tooth-on-chip is a new platform that replicates near-physiological conditions of the pulp-dentin interface and enables live cell imaging to study the response of the tooth pulp to biomaterials.
Neither did we.